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Based on analysis of biological processes in the same low expression Parathyroid Hormone-Like Hormone (PTHLH) activated feedback mitosis and downstream DNA replication-mediated cell proliferation Gene Ontology (GO) network of no-tumor Hepatitis/Cirrhotic Tissues (HBV or HCV infection) compared with the corresponding high expression (fold change ≥2) activated (Gene Ontology) GO network of human Hepatocellular Carcinoma (HCC), we proposed PTHLH activated network that upstream consisted of cell division, cell proliferation, mitosis, mitotic checkpoint, nucleosome assembly, spindle organization and biogenesis; Downstream network cell cycle, cell cycle arrest, centrosome cycle, chromosome segregation, DNA replication, DNA replication checkpoint, G1/S transition of mitotic cell cycle, mitotic chromosome condensation, mitotic G2 checkpoint, mitotic spindle checkpoint, positive regulation of cell proliferation, regulation of cell proliferation, traversing start control point of mitotic cell cycle, positive regulation of DNA repair, postreplication repair, DNA damage response, response to DNA damage stimulus, cell division, cell proliferation, mitosis, mitotic checkpoint, nucleosome assembly, spindle organization and biogenesis, as a result of feedback mitosis to downstream DNA replication coupling postreplication repair-induced cell proliferation in no-tumor hepatitis/cirrhotic tissues. Our hypothesis was verified by the different PTHLH activated feedback mitosis and downstream DNA replication-mediated cell proliferation GO network of no-tumor hepatitis/cirrhotic tissues compared with the corresponding inhibited GO network of HCC, or the same compared with the corresponding inhibited GO network of no-tumor hepatitis/cirrhotic tissues. We constructed PTHLH feedback mitosis to downstream DNA replication coupling postreplication repair-induced cell proliferation network that upstream BUB1B activated PTHLH, and downstream PTHLH-activated BUB1B, CCNA2, CDC6, BRCA1 in no-tumor hepatitis/cirrhotic tissues from (Gene Expression Omnibus) GEO data set using gene regulatory network inference method and our programming.

molecular biology

Parathyroid Hormone-Like Hormone (PTHLH) Feedback Mitosis to Downstream DNA Replication Coupling Postreplication Repair-Induced Cell Proliferation Network in No-Tumor Hepatitis/Cirrhotic Tissues (HBV or HCV Infection) by Systems-Theoretical Analysis