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Interstitial Lung Diseases (ILD) is a group of diseases characterized by poor prognosis and high mortality. Patient’s symptoms are dyspnea and cough, which directly affect Health-Related Quality of Life (HRQoL). Information about incidence, prevalence and mortality in ILD is scarce in Latin America, so it is difficult to estimate the magnitude of the problem. In ILD the decrease in HRQoL frequently is originate by emotional distress, anxiety and depression as two of the most common problems associated. Our aim was to assess the frequency of anxiety and depression in ILD patients from two specialized centers in Latin American. Additionally, we analyze the relationship between mood alterations and clinical variables with HRQoL. We developed a cross-sectional study, with 149 patients; we used Hospital Anxiety and Depression Scale (HADS). Of all patients 27% had anxiety and depression, argentine cohort with higher means (anxiety 6 ± 3 vs. 2 ± 2 and depression 5 ± 4 vs. 2 ± 2, p>0.0001). We found difference only in the forced vital capacity, which was lower in Mexican subgroup. Our findings indicate that ILD are associated with anxiety/depression problems and they have a direct impact in terms of quality of life in this cohort.

Prevalence of Anxiety and Depression and their Relationship with Clinical Characteristics in Patients with Interstitial Lung Disease