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Background: Dental bonding agent (DBA) manufacturers continue to make their products more attractive to practitioners by simplifying their product placement protocol. The purpose of this study was to compare shear bond strength (SBS) of alternate protocols of a sixth generation DBA  Methods: 140 caries free human molars were placed in 7 groups (n=20). Groups Part 1 A-C: manufacturers' recommended protocol and two alternate adhesive layer application techniques. Groups Part 2 A-D: manufacturers' recommended protocol and two alternate primer layer application techniques and manufacturer's total etch protocol. Deep dentin surfaces were exposed, polished, DBA's and universal nanohybrid composite placed. After48hours, SBS was tested with universal testing machine. Samples of each group were prepared and imaged for descriptive assessment with CLSM. Results: One-way ANOVA showed significant difference between groups In Part 1. (P < .001) Post hoc tests showed group A had significantly higher SBS than both adhesive alternative groups B and C. In Part 2.One-way ANOVA showed no significant difference (P=.067) between groups. Post hoc tests showed groups A-Cwith significantly higher SBS than group D but not among themselves. Conclusions: The alternate primer placement protocols for the sixth generation DBA tested compared favorably with the manufacturers recommended protocol when comparing SBS. 1.5. Practical Implications: There may be some flexibility in placement of the sixth generation DBA Primer tested without significantly affecting its performance; however, the adhesive layer application should not be altered from manufacturer's recommendation.

Comparison Of Alternate Protocols For Placing A Sixth Generation Dental Bonding Agent