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Copyright: © 2012 Hodge S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. It is becoming increasingly evident that pulmonary macrophage dysfunction contributes to disease pathogenesis in a variety of chronic lung diseases including chronic obstructive pulmonary disease (COPD) [1], bronchiolitis obliterans syndrome (BOS) following lung transplantation [2], cystic fibrosis (CF) [3] and severe asthma (NEA) [4]. An abnormal accumulation of apoptotic bronchial epithelial cells with an associated defect in the phagocytic ability of neighboring macrophages (efferocytosis) can lead to secondary necrosis of the uncleared apoptotic material with pro-inflammatory effects [5,6]. Specific therapeutic targeting of the macrophage dysfunction is being increasingly studied. The actual progression of this strategy to clinical use is however still very much in the early stages and much of our knowledge of the potential impact of macrophage-targeted therapies has evolved in retrospect rather than from a direct developmental approach.

Pulmonary Macrophage-Targeted Therapies-The Way Forward in Chronic Inflammatory Lung Diseases?