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The research of isolation and characterization from the Indonesian’s Marine Sponge Xestospongia muta, Clathria sp. and Endectyon delaubenfelsi as anti-dormant against Mycobacterium smegmatis has been conducted on May 2018. The bioactive compounds were isolated based on bioassay-guided separation with several steps of chromatography. The result of bioactivity showed different activity from Xestospongia muta (MIC50=0.2 μg/mL), Clathria sp. (MIC50=0.9 μg/mL) and Endectyon delaubenfelsi (MIC50=0.4 μg/mL). The results of FTIR spectrum interpretation of Xestospongia muta has vibration at 3435.56 cm-1 indicate as O-H alcohol functional group with the confirmation of the C-O alcohol at 1342.24 cm-1 in the fingerprint region. The active metabolite has C≡N imine at 2365.28 cm-1 with the confirmation of C-N imine at 1637.27 cm-1 in the fingerprint region. Based on MIC50 data shows that Xestospongia muta has potential cytotoxic against Mycobacterium smegmatis.

Bioactivity of Indonesian’s Marine Sponge Xestospongia muta as Antidormant Mycobacterium smegmatis