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Coxsackievirus B3 (CVB3) induced myocarditis is sex dependent with males developing more severe disease than females. Previous studies had shown that sex-associated hormones determine the sex bias with testosterone and progesterone promoting myocarditis while estrogen (E2) is protective. There are two major estrogen receptors: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). The goal of the current study was to determine the relative role of these receptors to myocarditis susceptibility and the mechanism of their action.

ERÃÂ² and ERÃÂ± Differentially Regulate NKT and VÃÂ³4+ T-cell Activation and T-regulatory Cell Response in Coxsackievirus B3 Infected Mice

ERÃÂ² and ERÃÂ± Differentially Regulate NKT and VÃÂ³4+ T-cell Activation and T-regulatory Cell Response in Coxsackievirus B3 Infected Mice