Volume Resuscitation in Sepsis

Fluid resuscitation in sepsis is the subject of long and complicated debate. Recent research has called into question several entrenched clinical positions. Currently, crystalloid, titrated to specific hemodynamic parameters is the leading modality of resuscitation in early shock. Central venous pressure, mean arterial pressure, and oxygen saturation of mixed venous blood are the indices which measure the adequacy of fluid resuscitation therapy. Lack of more accurate and earlier predictors of sufficient fluid resuscitation precludes even more effective therapeutic measures. In this review we examine the current evidence that drives fluid resuscitation therapy.