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In recent years, compounds containing in skeleton chromane moiety have gained the huge interest of medicinal chemists. Chromane and its derivatives are important intermediates and interesting building-blocks in organic synthesis and drug design. Beyond the most well-known derivatives of vitamin E with antioxidant properties [1], flavones, 3-benzylidene, 4-chromanone, or chiral dihydrocoumarin derivatives have attracted much attention due to their pharmacological and physiological activities such as anti-inflammatory, HIV replication inhibition and antioxidant [2, 3]. A group of phenylalanine and 2-chromanone derivatives was found to be the β-lactamase substrates [4]. Inhibition of those enzymes plays the crucial role in the discovery and development process of new active β-lactam antibacterial agents [5]. Together with the isolation from nature or synthetic studies of new active compounds their chemical analysis calls for access to modernized methods for in-depth structural characterization. The boundaries in this field lie in an improvement of detection sensitivity of small quantities, separation of complex mixtures of compounds, and in the elucidation of the stereostructure of components [6]. The assignment of absolute configuration (AC) of organic molecules still remains as one of the most important challenges in modern organic chemistry.

Application of On-line HPLC-CD Detection in Separation and Structure Elucidation of Tricyclic Cephalosporine Oxaanalogues with Chromane Moiety