Effect of malathion on liver ache activity of mice

An experiment was conducted to study the effect of malathion toxicity on acetylcholinesterase activity in mice liver. Mature mice were exposed to different doses of malathion for different time period. On dissections, enzymatic estimations were done for each exposure period. It was found that, malathion inhibited the acetylcholinesterase activity in mice liver .The maximum period of exposure was upto 30 days. The degree of inhibition increased upto 4 days of exposure period but declined later on. There was maximum recovery of AChE activity by 30th day of exposure. These findings indicate that the continuous and prolonged exposure to sublethal dose of malathion resulted in the recovery of AChE activity.