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Transforming growth factor-beta (TGF-β) is a cytokine implicated in the susceptibility, development, and progression of gastrointestinal cancer and certain other neoplasms. In the later stages of cancer, TGF-β not only acts as a bystander of host-immune response, but also contributes to cell growth, invasion, and metastasis. In the current study, we generated gastric mucosal cells that stably express Smad7, and explored the Helicobacter pylori -associated biological changes between mock-transfected and Smad7-transfected RGM1 cells.

Role of Inhibitory Transforming Growth Factor-β Signal Smad7 inHelicobacter pylori-associated Gastric Damage