Open AccessIs Classification of Gastric Cancer According to Distinct Therapeutic Targets Applicable in Clinical Practice?
Author(s) -
KyoungMee Kim
Publication year - 2013
Publication title -
korean journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.203
H-Index - 25
eISSN - 2233-6869
pISSN - 1598-9992
DOI - 10.4166/kjg.2013.62.2.140
Subject(s) - medicine , cancer , clinical practice , computational biology , bioinformatics , family medicine , biology
: , 135-710, 81, Correspondence to: Kyoung-Mee Kim, Department of Pathology, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: +82-2-3410-2800, Fax: +82-2-3410-6396, E-mail: kkmkys@skku.edu Financial support: None. Conflict of interest: None. : . Deng , . high-resolution single nucleotide polymorphism arrays (copy number alterations) , 193 , 40 , 98 . . 22 (13 9 ). , FGFR2 (fibroblast growth factor receptor 2), ERBB2 (HER2/ERBB2, human epidermal growth factor receptor 2) KLF5 (Kruppel-like factor 5), GATA6 (GATA binding protein 6, globin transcription factor 6) . (receptor tyrosine kinase, RTK) Kirsten rat sarcoma viral oncogene homolog (KRAS) . , KRAS . FGFR2 FGFR/ VEGFR (fibroblast growth factor receptor/vascular endothelial growth factor receptors) dovitinib FGFR2 . 5 , FGFR2 (9%), KRAS (9%), EGFR (8%), ERBB2 (7%) MET (met proto oncogene) (4%) 37% /RAS .
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