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The objective of this study was to predict properties of pharmaceutical products prepared by a continuous twinscrew granulator (TSG) using compression test of wet granulated masses. The compressibility of granules prepared by the TSG were also investigated. The pressure transmission, G, which was obtained by the compression test of wet granulated masses, showed good correlation with granules and tablets properties. The relationships between G and the granule properties can be explained by densification of solid-liquid mixture followed by coalescence and layering of ungranulated powder and small granules. Based on the analysis of force-displacement profile, the tablet strength was found to be correlated with plastic energy and elastic recovery which was calculated using elastic energy and compression energy. The investigation of the compressibility of granules with or without binder in the formulation revealed that the improvement of binder dispersion, which was associated with increasing G, appeared to affect the tablet properties.

Prediction of Pharmaceutical Product Properties by Compression Test of Wet Granulated Masses