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Stromal-derived-factor-1 (SDF-1) and the G-protein-coupled receptor CXCR4 are involved in several physiological and pathological processes including breast cancer spread and progression. Several CXCR4 antagonists have currently reached advanced development stages as potential therapeutic agents for different diseases.

Identification of Novel 2-(1 H -Indol-1-Yl)-Benzohydrazides Cxcr4 Ligands Impairing Breast Cancer Growth and Motility