English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Two microsized graphite-design sensors based on ionophore technique, polyvinyl chloride carboxylated (PVC-COOH) and -cyclodextrin ( β-CD), are used for fabrication of two membrane sensors for the two studied drugs, metronidazole (MZ), sensor 1, and spiramycin (SP), sensor 2. Fast and stable Nernstian responses near 1x10 -5 - 1x10 -3 M for MZ and 1x10 -5 -1x10 -2 M for SP over pH range 5.5-7.5 for the two electrodes reveal the performance characteristics of these electrodes which have been evaluated according to IUPAC recommendations. The aim of this work is to develop a new, simple, accurate and precise method for the determination of MZ and SP in their binary mixtures, which can be applied in routine quality control. The method is successively applied for the determination of the two drugs in their pharmaceutical formulations. Validation of the method according to the quality assurance standards shows suitability of the proposed electrodes for the use in the quality control assessment of these drugs. The recovery percentages for the determination of the two drugs by the two proposed selective electrodes are 99.86 ± 0.249 % and 99.69 ± 0.856% for sensors 1 and 2, respectively. Statistical comparison between the results obtained by this method and the reported one is done and no significant difference is found.

Microsized Graphite Sensors for Potentiometric Determination of Metronidazole and Spiramycin