English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer.We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95% CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95% CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95% CI 1.048-1.816, p= 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95% CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95% CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95% CI 0.969-1.661, p= 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.

A meta-analysis of the association between CTLA-4 +49 A/G, −318 C/T, and IL-1 polymorphisms and susceptibility to cervical cancer