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9-Hydroxypheophorbide-a (9-HpbD-a), a new photosensitizer was extracted from the green alga Spirulina platensis. The anticancer effects of photodynamic therapy (PDT) treatment using 9-HpbD-a against human head and neck cancer cell HN3 and in vivo mice model were investigated. Cells were incubated with 9-HpbD-a for at least 6 hours or more followed by the laser irradiation. Cytotoxicity of 9-HpbD-a against HN3 cell was determined using the MTT assay, propidium iodide and Hoechst 33342 staining and transmission electron microscopy (TEM). To determine the mechanism of cell death, Western blot analysis was performed. The antitumor effect was confirmed in a cancer cell xenograft nude mouse model by photodynamic therapy (PDT) using 9-HpbD-a. For normal control and the 9-HpbD-a only treated group, tumor tissues showed continuous tumor growth (100%). For laser only treated experimental group, 3 treatments showed no remission (75.0%), and was one recurrence (25.0%). Out of 16 tumors in the fourth group of photodynamic treatment, 10 cured (62.5%), 4 recurrence (25.0%), and 2 did not heal (12.5%) were confirmed. PDT using a 9-HpbD-a and 665 nm diode laser showed significant antitumor effects. Thus PDT using 9-HpbD-a can be a useful new treatment method in the treatment of cancer in the future.

The apoptosis pathway of photodynamic therapy using 9-HpbD-a in AMC-HN3 human head and neck cancer cell line and in vivo