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Oxidative and nitrosative stress triggers an extensive damage to the tissues. Many herbal and chemical medicines have claimed to possess antioxidant properties. Arbutin exists in some plants such as Pyrus Biossierana Bushe. In this study, an inhibitory effect of arbutin against tert-butyl hydroperoxide induced cytotoxicity was studied using SYTOX TM Green assay for cell viability. The antioxidant effects of arbutin on the generation of malondialdehyde, nitric oxide, activity of oxidative enzyme (Superoxide dismutase and catalyze) and the amount of total thiol in Hep-G2 cells exposed to tert-butyl hydroperoxide were evaluated.

Is arbutin an effective antioxidant for the discount of oxidative and nitrosative stress in Hep-G2 cells exposed to tert-butyl hydroperoxide?