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A total of 180 weanling pigs (PIC TR4 ×1050, initially 11.1 lb and 21 d of age) were used in a 42-d growth trial to compare the effects of supplemental zinc, copper, and in-feed antimicrobial on weanling pig growth and antibiotic resistance of fecal Escherichia coli. There were 5 dietary treatments with 6 pens per treatment and 5 pigs per pen. Pens were assigned to dietary treatments in a randomized complete block design. Treatments were arranged in a 2 × 2 factorial design with main effects of copper sulfate (0 or 125 ppm) and zinc oxide (0 or 3,000 ppm for 14 d and 0 or 2,000 for 28 d). The fifth treatment was in-feed antimicrobial (50 g/ton neomycin sulfate and 50 g/ton oxytetracycline HCl). All diets were supplemented with165 ppm zinc and 16.5 ppm copper from the trace mineral premix. Fecal samples were collected from 3 pigs per pen on d 14 and 42 to determine total coliform and E. coli counts as well as E. coli antibiotic resistance rates.

Effects of copper sulfate, zinc oxide, and neoterramycin on weanling pig growth and antibiotic resistance rate for fecal escherichia coli