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Of all food safety challenges facing the beef industry, Escherichia coli O157:H7 has consistently presented the greatest economic remonstrance to meat packers and retailers. Cattle naturally shed E. coli O157:H7 in their feces, and it is a source of carcass contamination at harvest. If contaminated trim enters the food supply and is subsequently prepared incorrectly, it can lead to the human condition known as hemorrhagic colitis. In children or elderly people, an E. coli O157:H7 infection may lead to a more serious form known as hemolytic uremic syndrome, which is potentially lethal. Although the majority of previous research has been dedicated to reduction in contamination post-harvest, recent focus has shifted to pre-harvest mitigation of E. coli O157:H7. Post-harvest procedures are effective, so there is less room for improvement than in pre-harvest mitigation. Also, reducing the E. coli O157 burden entering the plant may improve the efficacy of post-harvest tools and ultimately reduce human illness.

A commercially available SRP vaccine reduces prevalence of E. coli O157:H7 in feces of beef cattle under commercial feedlot conditions