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Direct sequencing (DS) is the standard method for detection of epidermal growth factor receptor (EGFR) gene mutation in non-small cell lung cancer (NSCLC); however, low detection sensitivity is a problem. The aim of this study is to demonstrate higher detection rate of EGFR gene mutation with peptide nucleic acid (PNA) clamping compared with DS.

cancer research and treatment/cancer research and treatment

Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of &lt;i&gt;EGFR&lt;/i&gt; Gene Mutation in Patients with Non-small Cell Lung Cancer