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The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas.

Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with &lt;i&gt;De Novo&lt;/i&gt; Sarcomas

Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with <i>De Novo</i> Sarcomas