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Nesidioblastosis is a clinically, pathologically, and genetically heterogenous disease observed in neonates with persistent hyperinsulinemic hypoglycemia of infancy, but it is very rare in adults.1 Although progression from nesidioblastosis and islet hyperplasia to pancreatic tumors has been observed in an animal study using transgenic mice,2 islet cell tumors associated with nesidioblastosis in human are exceedingly rare.3,4 Herein we report a very unusual case of nesidioblastosis coexisting with a pancreatic non-functioning islet cell tumor in an adult with type 2 diabetes mellitus (type 2 DM).

Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus