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Cigarette smoke causes lipid peroxidation and results in an increase of malondialdehyde (MDA) level in blood that could finally lead to decreased lung function and respiratory disease. Herbs and spices like red ginger are known to have beneficial compounds for health. The aim of this study is to prove the effect of red ginger ethanol extract on blood MDA level of white male Wistar strain rats induced with cigarette smoke. 32 white male rats were divided into 4 groups. Group 1 was the negative control group, group 2 was the positive control group, group 3 was the one induced with cigarette smoke and 250 mg of red ginger ethanol extract and group 4 was induced with cigarette smoke and 500 mg of red ginger ethanol extract. Blood samples were taken on the baseline (day 0) and day 7 to be analyzed. MDA levels were measured using spectrophotometer. One Way ANOVA test and post hoc Tukey test were used to compare with the negative group. The study show significant differences (p=0,000) and the results were KN= 1,55; KP=4,45;J1=2,81;J2=1,65 (nmol/ml). Both doses of red ginger ethanol extract decrease blood MDA levels after 7 days treatment. Finally, it concludes that antioxidant content in red ginger ethanol extract can decrease MDA level.

proceedings of the proceedings of the 1st seminar and workshop on research design, for education, social science, arts, and humanities, seword fressh 2019, april 27 2019, surakarta, central java, indonesia

The Effect of Red Ginger Ethanol Extract on Blood MDA Level of White Male Wistar Strain Rats Induced with Cigarette Smoke