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Diarrhea is the second leading cause of death among children under five years old. There is a new paradigm that probiotic can be used as a supplement to treat diarrhea. Probiotic consists of lactic acid bacteria (LAB) that induce the immunity and increase absorption process in intestinal villi. In West Sumatera, there is traditional probiotic known as dadih made from fermented buffalo milk. In this study we aim to assess the effects of dadih supplementation on acute diarrhea duration, secretory immunoglobulin A and tumor necroting factor (TNF) alpha level in mice induced with enteropathogenic Escherichia coli (EPEC).In this experimental, analytical study, we used 30 mice induced with EPEC, divided into negative control group, positive control group induced with EPEC, and treatment group induced with EPEC and was given 112 mg dadih /20 gr BW daily for 14 days. Statistical analysis was performed using one way ANOVA, Kruskal Wallis and post hoc LSD. The result showed a mean of diarrhea duration was shorter in the treatment group (4.10 ± 1.52, p= 0.000). The mean of TNF-α level was lower in the treatment group (173.18 ± 70.48 p= 0.055), and mean sIgA level was higher in the treatment group (8.69 ± 2.43, p=0.208). Dadih administration shortened the duration of acute diarrhea, but did not show any statistically significant effects in the reduction of TNF-α, and increasing of sIgA level. The study showed that administration of dadih did not significantly affect sIgAand TNFα levels in mice given EPEC.

The Effects of Dadih Supplementation on Duration of Acute Diarrhea, Secretory Immunoglobulin A Level, and Tumor Necroting Factor Alfa Level in Mice Induced with Enteropathogenic Escherichia Coli