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Sir, Myasthenia gravis (MG) is an autoimmune disease and the most common disorder of the neuromuscular junction. In this disease, T‐cell‐mediated antibodies are directed toward acetylcholine receptors (AchR‐Ab) in the postsynaptic neuromuscular junction. In addition, ocular, bulbar, limb and respiratory muscle groups are typically involved.[1] Hepatitis C has been associated with multiple autoimmune conditions and was shown to be associated with MG in 4.8% of the patients.[2] Human T‐lymphotropic virus type 1 (HTLV‐1) has also shown to be associated with multiple autoimmune disorders,[3] including MG.[4] Here, the authors present a seronegative case of MG with reactive antibodies for hepatitis C and HTLV‐1.

Seronegative myasthenia gravis in association with human T-lymphotropic virus type 1 and hepatitis C