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| 2018 | 1 At a time (month), the rate of hemoglobin pool in hookworm infection at that time (H[t]) will be “fixed rate of red blood turnaround value‐0.00228t. Using integral equation to get the overall accumulated hemoglobin pool in hookworm infection, the final equation will be derived as “0 ∫ tH (t) = 12‐0.00228t2/2 = 12‐0.00114t2.” Nevertheless, this equation is based on the assumption that there is only 1 worm, hence the additional parameter to be considered is the number of worm. Here, the number of worm is assigned as X; then, the derived equation is “l2t – 0.00228t2X/2.” The expected hemoglobin level at different period simulating varied number of worm is shown in Figure 1.

Mathematical modeling for hemoglobin change due to blood loss due to hookworm infection