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Molecular-targeted ultrasound contrast agent (UCA) has improved the in vivo etiological analysis of various neoplastic diseases, particularly those associated with angiogenesis. For instance, a vascular endothelial growth factor receptor 2 (VEGFR2)-targeted UCA enabled earlier detection of pancreatic carcinoma (PC) by imaging using a transabdominal ultrasound (TUS) transducer;[1] however, the dynamics of molecular-targeted UCA use in PC tissues are yet to assessed by time-intensity curve (TIC) analysis. Furthermore, whether the tissue enhancement of molecular-targeted UCA can be identified using EUS with a miniaturized and strongly curved transducer remains unconfirmed. In this study, we evaluated the advantages of aVEGFR2-targeted UCA for PC imaging using an EUS transducer and analyzed the TIC parameters in vivo using allograft mouse models.

endoscopic ultrasound

Vascular endothelial growth factor receptor 2-targeted ultrasound contrast agent selectively accumulates in pancreatic carcinoma in the allograft mouse model: A pilot study using time-intensity curve analysis of EUS imaging