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Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder and is associated with metabolic syndrome (MS). Helicobacter pylori (H. pylori) infection (Hp-I) may be involved in the pathogenesis of both obstructive sleep apnea (OSA) and gastroesophageal reflux disease (GERD); the latter is also associated with OSAHS. An association between Hp-I and OSA has been reported as well as a potential association between Hp-I and insulin resistance, which represents the pathogenetic basis of MS. Objective To study the prevalence of Hp-I in patients with OSAHS having MS and its relation to both OSAHS and MS and to asses GERD symptoms in the studied groups and its relation to the severity of OSA and to Hp-I. Patients and methods This study included 28 patients with confirmed OSAHS by overnight polysomnography, with half of them having MS. Demographic, comorbidities, anthropometric, and clinical data were collected. Stool analysis for H. pylori antigen was done. Results Patients with OSAHS with MS had significantly more severe OSA (P≤0.001FNx01). The prevalence of both Hp-I and GERD was significantly higher in the MS group (P=0.023 and 0.018, respectively). GERD was significantly associated with H. pylori infection in the studied groups (P<0.001). The prevalence of Hp-I and GERD increased with the severity of OSAHS, but it did not reach statistical significance, as in patients with mild, moderate, and severe OSAHS, the prevalence of Hp-I and GERD was 16.7, 50, and 64.3%, respectively, and 12.5, 25, and 62.5%, respectively. Conclusion H. pylori infection can be considered as a potential confounder involved in OSAHS and GERD pathophysiology associated with MS.

The prevalence of Helicobacter Pylori infection in patients with obstructive sleep apnea having metabolic syndrome and its relation to both disorders