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in Sub-Saharan Africa.2–4 Since then, VMMC has become one of the most promising interventions to reduce HIV transmission, and it now represents a key HIV prevention approach in Sub-Saharan Africa, with national programs established in 14 priority countries, resulting in nearly 19 million VMMCs, primarily in adolescent boys and men. The ShangRing has been commercially available in China since 2006, with no serious or severe adverse events reported related to its use. The device comes in a number of sizes to suit different penile circumferences, from neonates to adults. It has been safely used for circumcision in more than 1.4 million boys and men since it was introduced in China. Independent experts from a World Health Organization (WHO) Technical Advisory Group reported that over 99% of the circumcisions conducted in African studies using the ShangRing were safely and effectively performed with no serious adverse events.5 Devices like the ShangRing could potentially increase the productivity and efficiency of health care workers in Sub-Saharan Africa, allowing them to perform many more circumcisions per day, at a similar or lower cost. Much progress has been made over the past 10 years since that original article was published in Asian Journal of Andrology in 2008. In studies conducted in Kenya, Malawi, Uganda, and Zambia, the ShangRing has been shown to be safe, effective, and well-accepted by men and boys and by providers of adult and adolescent VMMC services.6–11 The device received a CE mark in 2008, FDA 510(k) clearance in 2012, and the WHO prequalification in 2015. In addition, the use of this innovative no-flip ShangRing technique, spontaneous detachment that reported in this article obtained a new amended WHO prequalification in March 2019. The ShangRing has also been registered for sale in several countries in Africa, including Kenya, Malawi, Namibia, Zambia, and Zimbabwe. Currently, the ShangRing is the only WHO prequalified device for use in boys and men aged 10 years or older in Africa. While the original ShangRing technique has proven to be very quick, safe, effective, and easy, the procedure has since evolved based on work done in China, to facilitate an even simpler and easier procedure. The results of a study in Kenya show that two of these innovations, a modification of the original technique, called the “no-flip technique,” and spontaneous detachment, where the ring is allowed to fall off on its own (as opposed to removing it 7 days after circumcision), are safe, effective, and acceptable both to clients and providers.12 Other recent research, also conducted in Kenya, has shown that use of topical anesthesia instead of injectable anesthesia is also safe, effective, and acceptable.13 In March 2019, WHO amended the original prequalification to include use of these new innovations, the no-flip technique, spontaneous detachment and use of topical anesthesia. Use of the ShangRing could accelerate task-shifting from physicians to no-physician medical providers in Africa. Currently, there is ongoing work to assist countries in eastern and southern Africa, including Kenya, Malawi, Mozambique, Namibia, Tanzania, Uganda, and Zambia to introduce the ShangRing into national VMMC programs, which will provide these countries with an opportunity to increase the efficiency and acceptability of VMMC services and may reduce the cost to ensure longer-term sustainability of these programs. Studies are also getting underway in Kenya, Tanzania, and Uganda to explore the use of the ShangRing for early infant male circumcision using topical anesthesia. Commentary on “Simplifying the ShangRing technique for circumcision in boys and men: use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment”

asian journal of andrology/asian journal of andrology

Commentary on “simplifying the ShangRing technique for circumcision in boys and men: use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment”