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Background and Objective: The incidence of prostate cancer is increasing day by day worldwide. Prostate cancer in India is the 10 th most common malignancy affecting men although its incidence is rising in India. This study is designed to the effect of dyslipidemia, altered serum glucose, insulin resistance, and prostate-specific antigen (PSA) on the risk of prostate cancer. Materials and Methods: The study was conducted on a total of 150 patients, in which 75 patients were of prostate cancer considered as cases and 75 were healthy individuals as controls. About 8 ml of blood samples was drawn to determine fasting glucose, lipid profile, serum insulin, and serum PSA. Serum glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were measured using enzymatic kits of auto analyzer. Very low-density lipoprotein-C (VLDL-C) and LDL-C were calculated by Friedwald's formula. Serum insulin and serum PSA were estimated by immunoenzymatic assay. Body mass index (BMI) was calculated as weight in kilograms divided by height in meters squared (kg/m 2 ). Insulin resistance was assessed by homeostasis model assessment insulin resistance index (HOMA-IR) and calculated as follows: fasting glucose (mg/dL) × fasting insulin (mU/mL)/405. Blood pressure was measured in the sitting position after a 10 min resting period. Observation and Results: Clinical variables such as age, BMI, blood pressure, lipid profile, serum glucose, serum insulin, HOMA-IR, and serum PSA in case and control groups were compared using the unpaired Student's t -test. We found that BMI and the level of serum glucose, serum insulin, HOMA-IR, and serum PSA were significantly increased in prostate cancer patients as compared to control. In prostate cancer patients, HDL-C significantly decreased ( P P Conclusion: This study has shown significant association of high BMI, dyslipidemia, insulin resistance, and PSA with prostate cancer.

Relationship of dyslipidemia, insulin resistance, and prostate-specific antigen with prostate cancer