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Healthcare-associated (HCA) sepsis (known as late-onset/ nosocomial sepsis) is one of the leading causes of mortality and morbidity in neonatal intensive care units (NICU). Approximately 25% of premature neonates develop HCA sepsis during NICU stay based on published data. This figure is probably higher in limited resource countries. Every effort should be directed toward prevention rather than treatment of HCA sepsis. This article gives a practical approach to HCA sepsis and beyond the scope of pathophysiology, causative agents, risk factors and other aspects of classical review article.

Healthcare-associated sepsis in the neonatal intensive care unit: A Practical approach