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In 2012, the patient had undergone a total resection of an isolated occipital lesion histologically reported as glioblastoma multiforme (GBM), with wild‐type IDH1 and O‐6‐methylguanine‐DNA methyltransferase (MGMT) methylation. He had received concurrent adjuvant local radiotherapy (60 Gy) and chemotherapy (temozolomide). Because of local recurrence, two successive total resections were performed in May 2014 and July 2015 followed by chemotherapy (Temozolomide). In October 2015, a new local recurrence invading the superior sagittal sinus was diagnosed and treated with cyber Knife radiosurgery and concurrent introduction of Bevacizumab and rindopepimut, an investigational immunotherapy that targets the tumor specific oncogene EGFRvIII, followed by a rapid regression in size of the lesion.

Multilevel severe radiculopathy from an extraneural glioblastoma cervical metastasis