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The authors review a prospectively accrued database of consecutive patients to assess the effectiveness of the off‐label routine use of intrathecal fluorescein to detect an intraoperative cerebrospinal fluid (CSF) leak during endoscopic endonasal skull base surgery. Patients were pretreated with intravenous dexamethasone and diphenhydramine prior to administration of 25 mg of fluorescein injected immediately before surgery via lumbar puncture or lumbar drain. Basic white light illumination from the endoscope was used to identify the presence of unstained or fluorescein‐tinged CSF during the procedure. A dural reconstruction algorithm Neurosurgery concepts: Key perspectives on intrathecal fluorescein for detecting intraoperative cerebrospinal fluid leak during endoscopic endonasal surgery, spinal intraarterial chemotherapy, oligoastrocytoma classification by in situ molecular genetics, and prenatal myelomeningocele closure and the need for cerebrospinal fluid shunt placement

surgical neurology international

Neurosurgery concepts: Key perspectives on intrathecal fluorescein for detecting intraoperative cerebrospinal fluid leak during endoscopic endonasal surgery, spinal intraarterial chemotherapy, oligoastrocytoma classification by <i>in situ</i> molecular genetics, and prenatal myelomeningocele closure and the need for cerebrospinal fluid shunt placement