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Obtaining tissue confirmation of the underlying pathology is the gold standard for establishing the etiology of nontraumatic vertebral compression fractures. However, newer investigative modalities such as the magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) combined potentially offer the ability to distinguish between benign and malignant lesions, thereby circumventing the need for invasive tissue diagnostic/biopsy procedures.

surgical neurology international

The role of magnetic resonance imaging and positron emission tomography-computed tomography combined in differentiating benign from malignant lesions contributing to vertebral compression fractures