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Cisplatin (CP) as a potential chemotherapeutic drug is accompanied with nephrotoxicity[1] and hepatotoxicity.[2] Aerobic exercise could attenuate CP‐induced nephrotoxicity gender dependently.[3,4] The experimental design was described before[3,4] briefly, sixty Wistar rats were divided into eight groups. The male animals in Group I (named EX + CP + EX) had aerobic exercise on a treadmill 1 h/day and five days/week for 8 weeks. Then, the exercise protocol was continued for another week which was accompanied with reducing the intensity of training, and during this week, the animals also received CP (2.5 mg/kg/day). Groups II (named EX + CP) had the same protocol as Group I without exercise in the last week during CP therapy. Groups III (named CP) and IV (named sham) received CP and saline respectively during the last week of the study without exercise. The female rats in Groups V–VIII had the same protocol as the male rats in Groups’ I–IV. The animals were exposed to moderate exercise with the 65% oxygen consumption.[5] Blood samples were obtained 1 week after CP administration.

Sex-related difference in protective role of aerobic exercise against cisplatin-induced hepatotoxicity