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Certain specific bacterial species from the subgingival biofilm have demonstrated etiological relevance in the initiation and progression of periodontitis. Among all the bacteria studied, three have shown the highest association with proximal caries and bone loss: Fusobacterium nucleatum (Fn), Capnocytophaga (Ca), and Campylobacter rectus (Cr). Therefore, the relevance of having accurate microbiological diagnostic techniques for their identification and quantification is clearly justified.

Microbial pathogens associated with proximal dental caries in the primary dentition and their association with periodontal disease in children