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Fibromyalgia syndrome (FMS) is a pain syndrome originating from the muscle and its connective tissues and it is characterized by widespread noninflammatory pain, cognitive dysfunction, fatigue, sleep disturbance, and a heterogeneous complex of somatic symptoms [1]. It is more common in women, with an estimated prevalence of 1–2% in the adult population [2]. FMS is still a disease of unknown etiology. There are many pathologic mechanisms, which are postulated as a possible etiology of FMS; one of them is local hypoxia, which is suggested to play a potential role in the pathophysiology of disease manifestations [3].

Impact of an intensive dynamic exercise program on oxidative stress and on the outcome in patients with fibromyalgia