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A simple, rapid, and sensitive high performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed and validated for the simultaneous determination of ofloxacin (OFL) and cefixime (CEF) in human plasma using the moxifloxacin as internal standard.

A conventional HPLC-MS method for the simultaneous determination of ofloxacin and cefixime in plasma: Development and validation