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synthesis and extrapolation of the patient's history, physical examination and laboratory evaluation. Chetwood et al. reported a very unusual case of a 35-year-old obese male patient with a left ventricular thrombus secondary to a silent myocardial infarction and resultant shower emboli to multiple arterial sites. This rare and extreme example of a left ventricular thrombus in a young male patient emphasizes the potential sequelae of the condition. Saritas et al. presented several cases about the management of aortico-left ventricular tunnel. Wang et al. studied the modifi cation of atrioventricular node in a special condition treating paroxysmal supraventricular tachycardia. They found that, in some special cases, modifi cation of the atrioventricular node should rely on not only the junctional rhythm to determine the ablation effect but also on the cardiac electrophysiological examination. In the original articles of this issue, Nasr et al. showed allopurinol and global left myocardial function in heart failure patients. Allopurinol did not produce signifi cant clinical and functional improvements in unselected patients with moderate-to-severe heart failure. However, it suggested that it was useful in patients with elevated serum uric acid (SUA) in a manner according to degree of SUA reduction. SUA may serve as a valuable biomarker to target heart failure therapy. Morgado et al. conducted a cross-sectional survey in a hospital hypertension outpatient clinic located in the Eastern Central Region of Portugal. A total of 197 patients meeting the inclusion criteria and consenting to participate completed the interview. They found that poor medication adherence, lack of information about hypertension and side-effects should be considered as possible underlying causes of uncontrolled blood pressure (BP) and must be addressed in any intervention aimed to improve BP control. Saritas et al. evaluated the methods of percutaneous transcatheter interventions for combined congenital heart disease and its effi cacy in children. They concluded that multiple transcatheter interventions in the same session were feasible, safe and effective, with satisfactory good results. A second intervention may be performed as a complementary procedure or independently to the fi rst intervention. JCDR is now indexed with PubMed. We would like to thank all the reviewers for their excellent work and the authors Cardiovascular disease is a leading cause of morbidity and mortality worldwide. The Journal of Cardiovascular Disease Research (JCDR) is honored to publish the fourth issue dedicated to cardiovascular disease research. The aim of this issue is to combine the various perspectives of clinical …

Preface to the fourth issue of Journal of Cardiovascular Disease Research