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Background: Conventional management of Rhematiod Arthritis (RA) includes administration of Non- Steroidal Anti- Inflammatory Drugs (NSAIDs), disease modifying anti-rheumatic drugs (DMARDs) like Methotrixate and anti-tumor necrosis factor α monoclonal antibody (anti-TNFά). Gastric ulcers, bleeding and perforation are the most common known adverse reactions found associated with excessive consumption of NSAIDs. The homoeopathic system of medicine improves the general well being, that is, Quality of Life (QoL) in addition to reducing the pain and disability. Objective: To evaluate the patients with RA receiving homoeopathic medicines with respect to QoL, Disease Activity Score (DAS), Erythrocyte Sedimentation Rate (ESR), morning stiffness/pain and frequency of analgesics after homoeopathic intervention. Design: This is a retrospective analysis of the role of homoeopathic medicines in RA. Patients diagnosed as sero-positive for RA antigen receiving homeopathic medicines were analysed for DAS, QoL, frequency of analgesics, ESR and pain/morning stiffness. Materials and Methods: Ten cases testing sero-positive for RA with at least four clinical signs were evaluated from single homoeopathic Out-Patient Department (OPD) from February 2009 and February 2011. Cases were analysed to find out the role of homoeopathic constitutional similimum in people with RA. Changes in DAS, ESR, pain/morning stiffness and QoL were considered as outcome measure. Results: Homoeopathic constitutional medicines were found to reduce the intensity of pain in patients with RA (t = 4.3733, P < 0.01) along with reduction in consumption of NSAIDs (t = 2.4, P < 0.05). The DAS reduced in all 10 patients (t = 2.67, P < 0.01). The QoL was also found to improve under homoeopathic medication (t = 4.044, P < 0.01) and no further deterioration joint/disability was observed in any of the 10 patients. Mean ESR improved to 19.5 from 38.1 (t = 2.235, P < 0.05). Out of 10, 3 (30%) patients were found to be sero-negative after homoeopathic constitutional similimum. Conclusion: Homoeopathic constitutional similimum improves the QoL of patients with RA by reducing intensity of pain, limiting disability and reducing disease activity, thus causing improvement in general and disease condition in particular. It also limits the need of analgesics and DMARDs in RA

To evaluate the role of homoeopathic medicines as add-on therapy in patients with rheumatoid arthritis on NSAIDs: A retrospective study