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Fructus Corni is derived from the dry ripe sarcocarp of Cornus officinalis Sieb. et Zucc. 5-hydroxymethyl-2-furaldehyde (5-HMF) is an important active composition of the Fructus Corni. However, there have been no reports on the concentration of 5-HMF in freely moving rats using microdialysis coupled with HPLC.

pharmacognosy magazine

Determination of 5-hydroxymethyl-2-furaldehyde of crude and processed fructus corni in freely moving rats using in vivo microdialysis sampling and liquid chromatography