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signal of tissue hypoxia.[2] Above serum lactate, lactate clearance has been shown in recent times to be of prognostic value in community‐acquired pneumonia,[3] severe sepsis[4] congenital heart defects corrections such as arterial switch operation with regressed left ventricular.[5] In this issue, read on lactate clearance as a prognostic marker in Tetralogy of Fallot and also how endothelin, SCVO2, and lactate are related! Neutrophil gelatinase‐associated lipocalin (NGAL), in off‐pump coronary artery bypass grafting, makes interesting reading telling us about interrelations between renal function and ischemia and how to better outcomes. Lactate clearance, endothelin, NGAL, and albumin levels (particularly, in cyanotics, are here to stay and more randomized, multicentric trials are needed with evidence‐based algorithms to prove their utility.[6,7]

From lactate to soluble urokinase plasminogen activator receptor: The journey for ideal cardiac biomarker: Are we there in 2016?