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Imatinib is the standard first-line treatment for chronic myeloid leukaemia (CML) patients. About 20 to 30 per cent patients develop resistance to imatinib and fail imatinib treatment. One of the mechanisms proposed is varying expression levels of the drug transporters. This study was aimed to determine the expression levels of imatinib transporter genes (OCT1, ABCB1, ABCG2) in CML patients and to correlate these levels with molecular response.

indian journal of medical research

Molecular response to imatinib &amp; its correlation with mRNA expression levels of imatinib influx &amp; efflux transporters in patients with chronic myeloid leukaemia in chronic phase