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Background and Objectives: This cytogenetic study detects a wide variety of common, rare and novel chromosomal abnormalities in patients with hematological disorders, providing valuable diagnostic and prognostic information. Materials and Methods: We addressed the utility of the cytogenetic technique in 50 patients of pediatric acute leukemia prospectively. Results: Successful cultures were found in 44 patients (88%) and abnormal karyotypes in 22 (44%). The common abnormalities like hyperdiploidy, del(6q), t(1;19)(q23;p13), t(4;11)(q22;q23), t(9;22)(q34;q11), rare t(2;7)(q23;p11) and t(4;12)(q21;p13) and a novel translocation t(7;9)(q22;q21) were observed in acute lymphoblastic leukemia. In acute myeloid leukemia, t(8;21)(q22;q22), del(16)(q22), t(15;17)(q22;q21) and t(9;11)(p22;q23) were commonly seen. Conclusion: Chromosomal abnormalities of this small group of patients are compared with the relevant literature with respect to the incidence rate and prognosis.

Rare and recurrent chromosomal abnormalities and their clinical relevance in pediatric acute leukemia of south Indian population