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A 32 year-old man presented to our clinic with genital warts, which had been present for the last six months. Dermatologic examination revealed multiple verrucous papules on the shaft of the penis and pubic area and depigmented macules on the glans penis, the shaft of the penis and the scrotum [Figure 1]. Imiquimod 5% cream had been applied to the warts every other night. After two months, he had noticed erythematous lesions on the dorsal surface of the penis and the scrotum. These lesions turned into depigmented areas in three months. Depigmentation never extended to the areas that had not been treated with imiquimod. No repigmentation was noted in a six-month follow-up period. The patient had no personal or family history of vitiligo.

Successful use of imiquimod 5% cream in Bowen′s disease