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Sir, Free fatty acids constitute 10-30% of the human skin surface fat but occur in only small amounts in the skin lipids of most other animals.[1] This difference has been tentatively attributed to the rather unique bacterial flora of humans, in particular Propionibacterium acnes and its lipase action on sebum triglycerides. Analysis of pure sebum from isolated human sebaceous glands showed the presence of triglycerides but not free fatty acids, monoglycerides or diglycerides.[2] It has been suggested that unsaturated fatty acids, particularly oleic acid, play an important role in elimination of Streptococcus pyogenes and Staphylococcus aureus from human skin.[3]

A possible role for human follicle mites in skin's defense against bacteria