English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

To the Editor: Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant inherited disorders with a prevalence of approximately 1 in 3000 individuals.[1] Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Studies have suggested that NF1 associated GISTs (NF1‐GISTs) manifest at younger ages than sporadic GISTs; they tend to be located in the small intestine and they affect females predominantly.[1,2] Most sporadic GISTs are driven by activating mutations of KIT or PDGFRA. However, these mutations in NF1‐GISTs are very rare. Various mutation types GISTs coexisting in an NF1 patient are rarer still. Herein, we report a case of multiple GISTs in an NF1 patient. Mutation analysis of KIT and PDGFRA was performed in three tumors from different locations. Interestingly, the molecular analysis of the three tumors showed that one mutation was found in KIT exon 11 of the gastric GIST in this case, whereas the other two tumors from the duodenum and jejunum were identified as wild‐type KIT and PDGFRA.

Gastrointestinal Stromal Tumors with KIT Mutation Coexisting with Wild-type Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1