English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

To the Editor: Osteoarthritis (OA) has the highest prevalence and economic impact among arthritic maladies and is the most common cause of long‐term disability among individuals over 65 years of age. OA is characterized by the degeneration of articular cartilage and the loss of cartilage matrix in affected joints. It is widely accepted that an imbalance between the biosynthesis and the degradation of extracellular matrix (ECM) occurs in OA cartilage, leading to degeneration and gradual cartilage loss. During the onset and progress of OA, changes occur in the composition of the ECM, which is composed primarily of type II collagen and aggrecan (AGC). The breakdown of AGC is believed to be initiated by a disintegrin and metalloproteinase with thrombospondin‐like motifs (ADAMTS)‐4 and ADAMTS‐5.[1]

chinese medical journal/chinese medical journal

Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs