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To the Editor: A 50‐year‐old man was admitted to Peking Union Medical College Hospital with recurrent abdominal pain, vomiting, and melena. In the past 2 years, he had visited several hospitals for abdominal discomfort and was diagnosed as ileus or subileus. Normal mucosa was shown in both gastroscopy and colonoscopy. Three months before admission, the patient started suffering from recurrent hematemesis and melena. Physical examination only showed abdominal tenderness, without lymphadenopathy. His hemoglobin was 94 g/L. The lymphocyte count, platelet count, liver function, tumor markers, and erythrocyte sedimentation rate (ESR) were normal. Antinuclear antibodies, anticytoplasmic antibodies, and anti‐saccharomyces cerevisiae antibody were undetectable. Small‐bowel barium enema showed multiple ulcerations and stenosis in the jejunum and proximal hold‐up [Figure 1a]. Computed tomography (CT) confirmed the presence of multiple jejunal strictures, prestenotic dilation, and bowel wall thickening [Figure 1b]. The 18F‐fluorodeoxyglucose positron emission tomography‐CT (PET‐CT) suggested intestinal inflammation. The appearance of skip lesions made us consider a rare disease called cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). Thus, the patient was treated with 40 mg daily prednisone, which was slowly tapered. Significant clinical improvement occurred and the patient was discharged.

Intestinal Mucosal-Associated Lymphoid Tissue Lymphoma Mimicked Cryptogenic Multifocal Ulcerous Stenosing Enteritis