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Previous studies have reported that auditory verbal hallucinations (AVHs) may be caused by resting‐state neuronal hyperactivity in the default mode network (DMN). Abnormally increased functional connectivity (FC) between the DMN and other cortical regions may cause disturbances in neuronal network architecture and interactions. Subsequently, disturbed neuronal network architecture and interactions may induce increased activation in auditory and speech perception areas in the absence of external auditory stimuli as well as reduced activation in the same areas in the presence of external auditory stimuli. These disturbances may be the neural basis of AVHs.[1] In addition, insight, which is another core characteristic of schizophrenia, has been associated with treatment compliance, relapses, long‐term outcomes, and global functioning ability. Some studies have reported that insight is also related to disturbance of the DMN, especially self‐monitoring: poor insight is associated with increased connectivity between the self‐referential network and the left insula.[2] The self‐referential network may be considered a component of the DMN.[2,3] Based on the aforementioned findings, we found that DMN alteration is associated both with AVHs and with insight. However, to the best of our knowledge, no one has yet studied FC patterns (FCPs) between the DMN and other brain regions associated with AVHs in schizophrenic patients with and without insight. Aberrant FCPs between DMN and other brain regions might play a key role in the interaction between AVHs and insight.

chinese medical journal/chinese medical journal

Aberrant Functional Connectivity Patterns of Default Mode Network May Play a Key Role in the Interaction between Auditory Verbal Hallucinations and Insight